The Epstein-Barr virus (EBV), a widespread human herpes virus with B-lymphocyte tropism, is the causative agent of infectious mononucleosis, and is strongly associated with several human malignancies. Infection with EBV is common and is generally subclinical or presents as a self-limited illness lasting 2 to 3 weeks. As a member of the herpes family, EBV can remain latent for long periods of time, and become reactivated at a later stage. Though the initial infection may result in a relatively benign syndrome, reactivation in an immunocompromised person can lead to more serious results. Monitoring of EBV viral load may help with the identification of post-transplantation lymphoproliferative disorders, and monitoring lymphomas in patients with the acquired immunodeficiency syndrome.1,2
1. Au W-Y et al, Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients. Blood, 1 July 2004 _ Volume 104, Number 1; 243-249.
2. Cornelissen J, Molecular monitoring of EBV-positive lymphoma. Blood, 1 July 2004 _ Volume 104, Number 1; 9.
Why to choose it
A reliable and accurate assay for quantitation of Epstein-Barr virus (EBV) nucleic acids in whole blood specimens.
Reliable performance that you can count on
The Simplexa™ EBV Kit has a sensitivity of 900 copies/mL and targets a well conserved region of the Lmp2A gene.
SimplexaTM EBV Kit
|Sensitivity900 copies/mL||Linear range900 copies/mL to 807 million copies/mL
(2.95 log copies/mL to 8.91 log copies/mL)
|CalibrationExternal five point calibration
EBV amplicon in human base matrix
|TargetWell conserved region
of the Lmp2A gene
Simplexa™ EBV Kit
|Code MOL2400||Reactions 100|
Simplexa™ EBV Quantitation Standards
|Code MOL2410||Reactions 5 x 400 µL|
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