Human cytomegalovirus (CMV), a beta herpes virus, is a member of the human herpes virus family.1 Infection with CMV is common in all human populations and approximately 70% or more of adults are seropositive for CMV antibodies, indicating previous infection with the virus.
As with all herpes viruses, CMV establishes latent infection in the host after recovery from the acute infection. Reactivation of the virus can occur after immunosuppression or other illnesses. CMV in immunocompromised patients is a well-known cause of morbidity and mortality.2
Monitoring by quantifying the levels of CMV in blood and plasma is critical for the effective management of these patients, driving changes in immunosuppression regimes, implementation of antiviral therapy or preemptive treatment. Once the diagnosis is made, a test capable of monitoring and quantifying the presence of CMV in blood and plasma is critical for the efficient and effective management of CMV infection in these patients.3,4
1. Mocarski, E. S. (1993) Cytomegalovirus biology and replication, p 173-226 In B. Roizman, R. J. Whitley, and C. Lopez (ed), the Human Herpesviruses. Raven Press, New York, N.Y.
2. Griffiths, P. D. and Emery, V.C. (2002) Cytomegalovirus, p 433-461 In D. D. Richman, R. J. Whitley, and F. G. Hayden (ed), Clinical Virology second edition. ASM Press, Washington, D.C.
3. Kalpoe, J. S., et al or (A. C. M. Kroes, M. D. de Jong, J. Schinkel, C. S. de Brouwer, M. F. C. Beersma, and E. C. J. Claas) (2004) Validation of Clinical Application of Cytomegalovirus Plasma DNA Load Measurement and Definition of Treatment Criteria by Analysis of Correlation to Antigen Detection p. 1498–1504 Vol. 42, No. 4 JOURNAL OF CLINICAL MICROBIOLOGY.
4. Baldanti F, Lilleri D, Gerna G. Monitoring human cytomegalovirus infection in transplant recipients. J Clin Virol. 2008;41(3):237-41.
Why to choose it
A reliable and accurate assay for quantitation of cytomegalovirus (CMV) nucleic acids in whole blood and plasma specimens.
Reliable performance that you can count on
The Simplexa™ CMV Kit has a sensitivity of 713 IU/mL and has been aligned to the World Health Organization (WHO) standard for CMV testing.
SimplexaTM CMV Kit
|Sensitivity713 IU/mL||Linear range713 IU/mL to 396 million IU/mL
(2.85 log IU/mL to 8.60 log IU/mL)
|CalibrationExternal five point calibration
CMV amplicon in human base matrix
|TargetWell conserved region
of the UL83 gene
Simplexa™ CMV Kit
|Code MOL2200||Reactions 100|
Simplexa™ CMV Quantitation Standards
|Code MOL2210||Reactions 5 x 400 µL|
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